OK, pretty sure I got it now...
Replaced the twist grip sensor, and bike is now running much better. Rode 300+ miles this weekend, no real problems. Fuel economy is back in range and no power loss felt, throttle is more responsive.
As for replacing the sensor, that was a task. I pulled the sensor out just until I could reach the wiring, and removed the headlight and handlebar clamp shroud so I could feed the harness through. Gave one little pull, felt a pop, and started the bike to no throttle at all. Broke the connector in the bars....
What's more, the connector, which turned out to be two connectors at the end of a 6 inch extension harness, stuck in the bar, wedged against the start/run switch cluster harness. Couldn't get a fish tape, or any kind of snake, through at all. I removed the harness, found it to be extended with butt connectors, and rewired it with solders and shrink tube, much more reliable and not subject to failure when pulling back through the bars. Eliminated the connectors both on that harness and the twist grip sensor harness, soldered and shrink sealed all the way through.
The local dealer had a TGS with a long harness already, fit with extra length in my 18" rise bars, and that was nice to see as opposed to having to extend it.
Give it another few weeks, but seems like I got it right now...