I use the same set-up in my 08 FLHX. Engine seems to be a little quieter with the Mobil 1, and it shifts easier with the Spectro. Neutral is much easier to find running the Spectro.
When my wife took her 11 Heritage into the dealer for her 5000 mile service, I forgot to send some Spectro along with her and they filled it with Syn3. Within 50 miles, she asked me to "put the good stuff" back in. Given her lack of mechanical aptitude, that spoke volumes to me that the Spectro makes a difference.