I started running nitrogen in my Fatboy when I had to replace my first set of tires after they began wearing badly due to under inflation. I didn't notice the tires running low and checked them probably once a month. I have noted the nitrogen filled tires stay full much longer and I have had to add only once in the last 4 months, though I still check them monthly.
The beads sound like a gimmick to me.
The beads sound like a gimmick to me.