Going out a limb, I would have to say it'll lean it further. The drop in vacuum is more critical in say a heavily cammed car with a huge amount of overlap set up to run best in the high rpm ranges. It doesn't really apply in a fuel injected torquey motor like the V-Twin. The MAP sensor? reads the manifold pressure and makes adjustments to the fuel curve, not a vacuum sensor.
The SE stage 1 map from the dealer is still too lean in my opinion. Adding a fueler like a Dobeck Gen3 has two advantages, tuning for more power and adding fuel to cool an otherwise already hot running motor. A quality dyno shop can custom tune the map to squeeze every last ounce of power out of the motor but what do most of us really want with our FLH's. More USABLE power in the rpm range we ride. With it's earlier closing intake in the Andrews 21's and some others, that is exactly what you get.....more low end power. As I said before, my best recommendation from experience is a cam that produces more low end power coupled with a fuel "adder" piggybacked to the stock or dealer re-mapped ecm. I haven't heard many complaints if any, other than issues with folks having trouble dialing in the tuners by going crazy and moving the pots or zones all over the place. Small incremental tweaks to the tuner while road testing it netted me a very well behaved motor that really does pull like a tractor and is still very reliable. I have ridden friends FLH's and Heritage Softails with 95 BB kits, Stock 96's and 103's and this little 88 impresses all of us in roll on pulls. Nobody is leaving me behind. 40-70 mph pulls leaves them giving me that "seriously dude?" look. They swear I've done more to it than a simple cam and Dobeck.