I'd have to vote for Synthetic also. I've been using synthetics for years, way before Harley started selling the "blend" and then saying it was ok to put in the bikes. When I got my Road King and Ultra, first thing I did when I got home was to drain the cheap stuff out. I immediately put in Amsoil. Just my choice among synthetics.
Anyway, as most of the posts have mentioned it has super lubrication, doesn't break down like oil and keeps the motor a bit cooler. (Not much though so don't jump and down) I did notice that once I changed out the synthetic the engine and trans were quieter!.
If you're using a good oil filter (Harley's is actually pretty good in comparing oil filters) I change the syn out approximately every 4,000 miles. There is absolutely no reason to change out earlier. Remember it does not break down like the dino stuff.. You're just wasting monies if you do, but......if your a bit anal and gives you the warm and fuzzy feeling, then change out when ever you want since it is your scooter.
Also, when I'm out on the road, much easier to just change the oil filter out at 3, 500 or 4,000 miles and just top it off until I get home. The syn is still doing it's job as long as the filter is doing it's thing and it's really nice on those l-o-n-g trips. Just a thought.
Ugly John